Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both.

doi:10.1001/jama.290.7.929

Article

Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both.

JAMA - 20 Aug 2003

de la Hoya Miguel, Fernández Juan M, Tosar Alicia, Godino Javier, Sánchez de Abajo Ana, Vidart Jose A, Pérez-Segura Pedro, Díaz-Rubio Eduardo, Caldés Trinidad

Abstract excerpt

CONTEXT: Defects in X-chromosome inactivation distort sex ratio in mice. The BRCA1 gene is also involved in X-chromosome inactivation, suggesting the possibility that some sex-ratio distortion may be associated with BRCA1-related human cancer syndromes. OBJECTIVE: To determine whether BRCA1 mutat...

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Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both.

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