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Thresholds of Nitric Oxide-Mediated Toxicity in Human Lymphoblastoid Cells

19 Jul 2003

Abstract excerpt

A novel delivery system was used to study NO-mediated cyto- and genotoxicity in two human lymphoblastoid cell lines, TK6 (wild-type p53) and NH32 (p53-null but isogenic to TK6). The delivery system, which supplied NO and O(2) continuously by diffusion through gas permeable tubing, was found to maintain the NO and O(2) concentrations at constant, predictable values. Cellular rates of NO and O(2) consumption and...

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PMID: 12924928
DOI: 10.1021/tx0340448

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