Article
Nuclear transit of human zipcode-binding protein IMP1.
The Biochemical journal - 1 Dec 2003
Nielsen Jacob, Adolph Sidsel K, Rajpert-De Meyts Ewa, Lykke-Andersen Jens, Koch Grete, Christiansen Jan, Nielsen Finn C
Abstract excerpt
The human IMPs (insulin-like growth factor II mRNA-binding proteins) belong to a vertebrate zipcode-binding protein family consisting of two RNA recognition motifs and four K homology domains and have been implicated in cytoplasmic mRNA localization, turnover and translational control. In the present study, we show that IMP1 is capable of translocating into nuclei of NIH 3T3 fibroblasts and its immunoreactivity...
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