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Article

Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Sept 2003

Masuda K, Takegami K, An H, Kumano F, Chiba K, Andersson G B J, Schmid T, Thonar E

Abstract excerpt

This study was performed to determine if recombinant human osteogenic protein-1 (rhOP-1) is effective in promoting matrix synthesis and matrix formation by rabbit nucleus pulposus (NP) and annulus fibrosus (AF) cells cultured in alginate beads. The effects of culturing the cells in the presence of various concentrations of rhOP-1 were assessed by measuring changes in cell proliferation, proteoglycan (PG) and...

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PMID: 12919882
DOI: 10.1016/S0736-0266(03)00037-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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