Article
Model of the equine rhinitis A virus capsid: identification of a major neutralizing immunogenic site.
The Journal of general virology - 1 Sept 2003
Kriegshäuser Gernot, Wutz Gordana, Lea Susan, Stuart David, Skern Tim, Kuechler Ernst
Abstract excerpt
Mouse monoclonal antibodies (mAbs) were employed to select neutralization escape mutants of equine rhinitis A virus (ERAV). Amino acid changes in the ERAV mutants resulting in resistance to neutralization were identified in capsid protein VP1 at Lys-114, Pro-240 and Thr-241. Although the changes were located in different parts of the polypeptide chain, these mutants exhibited cross-resistance against all four...
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