Article
Transcriptional down-regulation of peroxisome numbers affects selective peroxisome degradation in Hansenula polymorpha.
The Journal of biological chemistry - 17 Oct 2003
Leao-Helder Adriana Nívea, Krikken Arjen M, van der Klei Ida J, Kiel Jan A K W, Veenhuis Marten
Abstract excerpt
We have isolated and characterized a novel transcription factor of Hansenula polymorpha that is involved in the regulation of peroxisomal protein levels. This protein, designated Mpp1p, belongs to the family of Zn(II)2Cys6 proteins. In cells deleted for the function of Mpp1p the levels of various proteins involved in peroxisome biogenesis (peroxins) and function (enzymes) are reduced compared with wild type or,...
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