Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype.

doi:10.1086/377098

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Article

Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype.

The Journal of infectious diseases - 15 Aug 2003

Aras Rahul A, Lee Yongchan, Kim Sung-Kook, Israel Dawn, Peek Richard M, Blaser Martin J

Abstract excerpt

The highly diverse bacterium Helicobacter pylori, which persistently colonizes the human stomach, provides models to study the role of genome plasticity in host adaptation. Within H. pylori populations from 2 colonized individuals, intragenomic recombination between cagA DNA repeat sequences leads to deletion or duplication of tyrosine phosphorylation sites in the CagA protein, which is injected by a type IV...

Topics

Amino Acid Sequence
Antigens, Bacterial
Apoptosis
Bacterial Proteins
Base Sequence
Cell Line
Cell Size
Coculture Techniques
Gastric Mucosa
Genetic Variation
Helicobacter pylori

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-8

Molecular Sequence Data

Phenotype

Phosphorylation

Recombination, Genetic

Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 12898434
DOI: 10.1086/377098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12898434-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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