Article
Helicobacter pylori genetic diversity within the gastric niche of a single human host.
Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001
Israel D A, Salama N, Krishna U, Rieger U M, Atherton J C, Falkow S, Peek R M
Abstract excerpt
Isolates of the gastric pathogen Helicobacter pylori harvested from different individuals are highly polymorphic. Strain variation also has been observed within a single host. To more fully ascertain the extent of H. pylori genetic diversity within the ecological niche of its natural host, we harvested additional isolates of the sequenced H. pylori strain J99 from its human source patient after a 6-year interval....
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