Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects.

Virchows Archiv : an international journal of pathology - 1 Nov 2003

Verga Laura, Concardi Monica, Pilotto Andrea, Bellini Ornella, Pasotti Michele, Repetto Alessandra, Tavazzi Luigi, Arbustini Eloisa

Abstract excerpt

Mutations of the LMNA gene encoding the lamin A and C nuclear envelope proteins cause an autosomal dominant form of dilated cardiomyopathy (DCM) with atrioventricular block (AVB). The aim of this study was to investigate ultrastructural nuclear membrane changes by conventional electron microscopy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Dilated
Share to Genes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Block

Share to Lamin Type A

Share to Microscopy, Electron

Share to Microscopy, Immunoelectron

Share to Muscle Cells

Share to Nuclear Envelope

Source

Identifiers

PMID: 12898247
DOI: 10.1007/s00428-003-0865-4

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12898247-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects.PMID 12898247Read ↗

Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption.Semantic proximity Read ↗

Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease.Semantic proximity Read ↗

The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases.Semantic proximity Read ↗

Modulation of cytoskeleton in cardiomyopathy caused by mutations in LMNA gene.Semantic proximity Read ↗

Nuclear envelope proteins and associated diseases.Semantic proximity Read ↗

Dilated cardiomyopathy caused by LMNA mutations. Clinical and morphological studies.Semantic proximity Read ↗

Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy.Semantic proximity Read ↗

Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations.Semantic proximity Read ↗

The nuclear envelope in muscular dystrophy and cardiovascular diseases.Semantic proximity Read ↗

Role of nuclear Lamin A/C in cardiomyocyte functions.Semantic proximity Read ↗

In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.Semantic proximity Read ↗

Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.