Article
Ser-256 phosphorylation dynamics of Aquaporin 2 during maturation from the ER to the vesicular compartment in renal cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2003
Procino Giuseppe, Carmosino Monica, Marin Oriano, Brunati Anna M, Contri Antonella, Pinna Lorenzo A, Mannucci Roberta, Nielsen Soren, Kwon Tae-Hwan, Svelto Maria, Valenti Giovanna
Abstract excerpt
Aquaporin 2 (AQP2) phosphorylation at Ser-256 by protein kinase A (PKA) is a key signal for vasopressin-stimulated AQP2 insertion into the plasma membrane in renal cells. This study underscores the possible role of phosphorylation at Ser-256 in regulating AQP2 maturation. AQP2-transfected renal CD8 cells were incubated with brefeldin A (BFA) to accumulate newly synthesized AQP2 in the endoplasmic reticulum (ER),...
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