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Article

Minocycline and doxycycline are not beneficial in a model of Huntington's disease.

Annals of neurology - 1 Aug 2003

Smith Donna L, Woodman Benjamin, Mahal Amarbirpal, Sathasivam Kirupa, Ghazi-Noori Shabnam, Lowden Philip A S, Bates Gillian P, Hockly Emma

Abstract excerpt

Huntington's Disease (HD) is an inherited neurological disorder causing movement impairment, personality changes, dementia, and premature death, for which there is currently no effective therapy. The modified tetracycline antibiotic, minocycline, has been reported to ameliorate the disease phenot...

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Identifiers

PMID: 12891671
DOI: 10.1002/ana.10614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12891671-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Minocycline and doxycycline are not beneficial in a model of Huntington's disease.PMID 12891671Read ↗

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Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.Semantic proximity Read ↗

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Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfoldingSemantic proximity Read ↗

Doxycycline: An essential tool for Alzheimer’s diseaseSemantic proximity Read ↗

Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease ModelsSemantic proximity Read ↗

Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.Semantic proximity Read ↗

Treatment with Tau fibrils impact Huntington's disease-related phenotypes in cell and mouse models.Semantic proximity Read ↗

Can minocycline prevent the onset of Alzheimer's disease?Semantic proximity Read ↗

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