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Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome

30 Jun 2006

Abstract excerpt

Almost all Down syndrome (DS) patients develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques and neurofibrillary tangles, after middle age. The mechanism underlying AD neuropathology in DS has been unknown. Abeta is the central component of neuritic plaques and is generated from APP by cleavage by the beta- and gamma-secretases. Here we show that beta-secretase activity is...

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PMID: 16816111
DOI: 10.1096/fj.05-5628com

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