Article
Prion protein gene polymorphisms in Saccharomyces cerevisiae.
Molecular microbiology - 1 Aug 2003
Resende Catarina G, Outeiro Tiago F, Sands Laina, Lindquist Susan, Tuite Mick F
Abstract excerpt
The yeast Saccharomyces cerevisiae genome encodes several proteins that, in laboratory strains, can take up a stable, transmissible prion form. In each case, this requires the Asn/Gln-rich prion-forming domain (PrD) of the protein to be intact. In order to further understand the evolutionary significance of this unusual property, we have examined four different prion genes and their corresponding PrDs, from a...
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