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Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells

24 Jun 2003

Abstract excerpt

Somatic nuclei can be epigenetically reprogrammed by factors present in undifferentiated embryonic stem (ES) cells. The acquisition of pluripotency by somatic genomes could render such cells a viable source of personalized cell type(s) for therapeutic application, avoiding the need for controversial therapeutic cloning. To investigate this possibility, we first determined the origin of transcripts in teratomas...

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PMID: 12889059
DOI: 10.1002/dvdy.10337

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