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Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation

4 May 2010

Abstract excerpt

The concept of reprogramming of somatic cells has opened a new era in regenerative medicine. Transduction of defined factors has successfully achieved pluripotency. However, during the generation process of induced pluripotent stem (iPS) cells, genetic manipulation of certain factors may cause tumorigenicity, which limits further application. We report that that a single transfer of embryonic stem (ES)...

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PMID: 20439621
DOI: 10.1182/blood-2010-02-269589

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