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Article

The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.

The Journal of biological chemistry - 3 Oct 2003

Kaiser Frank J, Möröy Tarik, Chang Glenn T G, Horsthemke Bernhard, Lüdecke Hermann-Josef

Abstract excerpt

The TRPS1 gene encodes a repressor of GATA-mediated transcription. Mutations in this gene cause the tricho-rhino-phalangeal syndromes, but the affected pathways are unknown. In a yeast two-hybrid screen with the C-terminal part of the murine Trps1 protein as bait, we obtained three yeast clones encoding two overlapping fragments of the 194 amino acids RING finger protein 4 (Rnf4). The overlap narrows down the...

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Source

Identifiers

PMID: 12885770
DOI: 10.1074/jbc.M306259200

Genes

TRPS1
RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.PMID 12885770Read ↗

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Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes.Semantic proximity Read ↗

Tricho-Rhino-Phalangeal Syndrome with Supernumerary TeethSemantic proximity Read ↗

The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles.Semantic proximity Read ↗

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