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Article

Gene expression and regulation in the extended longevity phenotypes of Drosophila.

Annals of the New York Academy of Sciences - 1 Apr 2001

Arking R

Abstract excerpt

We used both selection and single-gene mutagenesis studies to identify the mechanisms underlying the genetic control of longevity in Drosophila. The expression of the extended longevity phenotype (ELP) in our forward-selected strains depends on an early and specific upregulation of the antioxidant defense system (ADS) genes and enzymes, which results in decreased oxidative damage levels and a delayed onset of...

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PMID: 11795506
DOI: 10.1111/j.1749-6632.2001.tb05645.x

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