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Can Soy Phytoestrogens Decrease DNA Methylation in <i>BRCA1</i> and <i>BRCA2</i> Oncosuppressor Genes in Breast Cancer?

17 Feb 2012

Abstract excerpt

Although soy phytoestrogens have been postulated to exert a protective effect against breast cancer, the attendant mechanisms, in particular epigenetics underpinnings, have remained elusive. We investigated the putative effects on DNA methylation by two naturally occurring isoflavones, genistein and daidzein, in a study of the BRCA1 and BRCA2 oncosuppressor genes in breast cancer cell lines (MCF-7, MDA-MB 231,...

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Identifiers

PMID: 22339411
DOI: 10.1089/omi.2011.0105

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Can Soy Phytoestrogens Decrease DNA Methylation in <i>BRCA1</i> and <i>BRCA2</i> Oncosuppressor Genes in Breast Cancer?PMID 22339411Read ↗

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Genistein Induces the <i>p21WAF1/CIP1</i> and <i>p16INK4a</i> Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin ModificationSemantic proximity Read ↗

Effects of the Phytoestrogens Genistein and Daidzein on BRCA2 Tumor Suppressor Gene Expression in Breast Cell LinesSemantic proximity Read ↗

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