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Article

Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines.

The British journal of nutrition - 1 Oct 2012

Bosviel Rémy, Durif Julie, Déchelotte Pierre, Bignon Yves-Jean, Bernard-Gallon Dominique

Abstract excerpt

S-Equol is a metabolite resulting from the conversion of daidzein, a soya phyto-oestrogen, by the gut microflora. The potential protective effects of equol in breast cancer are still under debate. Consequently, we investigated the effects of equol on DNA methylation of breast cancer susceptibility genes (BRCA1 and BRCA2) and oncosuppressors in breast cancer cell lines (MDA-MB-231 and MCF-7) and in a dystrophic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22217331
DOI: 10.1017/S000711451100657X

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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