Article
Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jun 2003
Tomboc Marlah, Witchel Selma Feldman
Abstract excerpt
Premature pubarche (PP) appears to be a risk factor for the subsequent development of polycystic ovary syndrome (PCOS) during or after puberty. The clinical manifestations due to hyperandrogenism are influenced by androgen production, androgen metabolism, and androgen receptor activity. Glucuronidation by the UDP-glucuronyltransferase 2B (UGT2B) family of enzymes is one mechanism through which androgens are...
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