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Article

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.

The Biochemical journal - 15 Jul 2003

Munier-Lehmann Hélène, Chenal-Francisque Viviane, Ionescu Mihaela, Chrisova Petya, Foulon Jeannine, Carniel Elisabeth, Bârzu Octavian

Abstract excerpt

Nucleoside monophosphate kinases (NMPKs) are essential catalysts for bacterial growth and multiplication. These enzymes display high primary sequence identities among members of the family Enterobacteriaceae. Yersinia pestis, the causative agent of plague, belongs to this family. However, it was previously shown that its thymidylate kinase (TMPKyp) exhibits biochemical properties significantly different from...

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Identifiers

PMID: 12879903
DOI: 10.1042/BJ20030284
PMCID: PMC1223521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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