Article
Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarction.
Thrombosis and haemostasis - 1 Jan 2002
Li Yi-Heng, Chen Jyh-Hong, Tsai Wei-Chuan, Chao Ting-Hsing, Guo How-Ran, Tsai Liang-Miin, Wu Hua-Lin, Shi Guey-Yueh
Abstract excerpt
Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C. This study examined the possible association between the thrombomodulin -33G/A polymorphism and acute myocardial infarction. We recruited 278 patients (mean age 57.5 years, 241 men) with documented myocardial infarction and...
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