Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.

doi:10.1016/s0006-3223(02)01976-5

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Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.

Biological psychiatry - 15 Jul 2003

Thomas Elizabeth A, Laws Simon M, Sutcliffe J Gregor, Harper Clive, Dean Brian, McClean Catriona, Masters Colin, Lautenschlager Nicola, Gandy Samuel E, Martins Ralph N

Abstract excerpt

BACKGROUND: Apolipoprotein E (apoE) has been implicated in the pathology of AD ever since inheritance of the epsilon4 allele was shown to be an important risk factor for the development of AD. Apolipoprotein D (apoD) is elevated in association with several central nervous system disorders, including Alzheimer's disease (AD), and has been proposed to be an especially robust marker for brain regions specifically...

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Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.

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