Article
Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families.
International journal of cancer - 1 Jan 2008
Desjardins Sylvie, Belleau Pascal, Labrie Yvan, Ouellette Geneviève, Bessette Paul, Chiquette Jocelyne, Laframboise Rachel, Lépine Jean, Lespérance Bernard, Pichette Roxane, Plante Marie, Durocher Francine
Abstract excerpt
Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes BRCA1 and BRCA2, found in about 25% of high-risk families, as well as few other low penetrance genes such as ATM and CHEK2. Approximately two-thirds of the multiple cases families remain to be explained by mutations in still unknown genes. In a candidate gene approach to identify new genes potentially involved in...
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