Article
Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.
Journal of cancer research and clinical oncology - 1 Nov 2009
Huo Xiang, Lu Cheng, Huang Xinen, Hu Zhibin, Jin Guangfu, Ma Hongxia, Wang Xuechen, Qin Jianwei, Wang Xinru, Shen Hongbing, Tang Jinhai
Abstract excerpt
PURPOSE: BRCA1-interacting protein C-terminal helicase 1 (BRIP1) and zinc finger protein 350 (ZNF350) work with BRCA1 in tumor suppression procedures. Low penetrance variants of these three genes may jointly affect individuals' breast cancer susceptibility in general population. METHODS: We focused on potentially functional single nucleotide polymorphisms (SNPs) in the coding regions of BRIP1, ZNF350 and BRCA1...
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