Article
No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.
Journal of neuroimmunology - 1 Jul 2003
Breij Esther C W, van der Pol W-Ludo, van Winsen Lisa, Jansen Mark D, Dijkstra Christine D, van de Winkel Jan G J, Uitdehaag Bernard M J
Abstract excerpt
Anti-myelin IgGs occur in the cerebrospinal fluid (CSF) and serum of multiple sclerosis (MS) patients, and can induce inflammatory effector functions in leukocytes by crosslinking IgG receptors (FcgammaR). The efficiency of FcgammaR-mediated inflammatory processes is affected by functional polymorphisms of three Fcgamma receptors (FcgammaRIIa, FcgammaRIIIa, FcgammaRIIIb). The relevance of FcgammaR polymorphisms...
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