Article
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.
Molecular and cellular biology - 1 Aug 2003
Didier Christine, Broday Limor, Bhoumik Anindita, Israeli Sharon, Takahashi Shoichi, Nakayama Koh, Thomas Sheila M, Turner Christopher E, Henderson Scott, Sabe Hisataka, Ronai Ze'ev
Abstract excerpt
RNF5 is a RING finger protein found to be important in the growth and development of Caenorhabditis elegans. The search for RNF5-associated proteins via a yeast two-hybrid screen identified a LIM-containing protein in C. elegans which shows homology with human paxillin. Here we demonstrate that the human homologue of RNF5 associates with the amino-terminal domain of paxillin, resulting in its ubiquitination. RNF5...
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