Article
Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability.
Molecular and cellular biology - 1 Aug 2003
Liu Baoying, Liang Min-Hui, Kuo Yu-liang, Liao Wei, Boros Imre, Kleinberger Tami, Blancato Jan, Giam Chou-Zen
Abstract excerpt
Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia. The HTLV-1 transactivator, Tax, is implicated as the viral oncoprotein. Naïve cells expressing Tax for the first time develop severe cell cycle abnormalities that include increased DNA synthesis, mitotic arrest, appearance of convoluted nuclei with decondensed DNA, and formation of multinucleated cells. Here we report that...
Topics
- Adenoviridae
- Anaphase-Promoting Complex-Cyclosome
- Aneuploidy
- Animals
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cell Cycle
- Cell Cycle Proteins
- Cell Line
- Cell Nucleus
- Cell Survival