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Article

Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse.

Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2003

Martin Lisa J, Machado Antonio F, Loza M Angelica, Mao Gloria E, Lee Grace S, Hovland David N, Cantor Rita M, Collins Michael D

Abstract excerpt

BACKGROUND: This study examines interactions of a mutation in Pax3, embryonic sex, advanced maternal age, and arsenite exposure in the splotch (Sp) mouse model, with the aim of describing gene-environment interactions for neural tube defects and embryonic lethality. METHODS: Splotch heterozygous C57BL/6J mice were crossed to produce offspring of three genotypes with a common maternal genotype that were exposed to...

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Identifiers

PMID: 12854658
DOI: 10.1002/bdra.10006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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