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Article

ZZ made EZ: influence of inhibitor configuration on enzyme selectivity.

Journal of molecular biology - 18 Jul 2003

Rauh Daniel, Klebe Gerhard, Stürzebecher Jörg, Stubbs Milton T

Abstract excerpt

Selectivity of drug targeting is necessary in order to forestall undesired side-effects. Here, we examine the structural grounds for the configuration-dependent selectivity of 2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one (1) for factor Xa and trypsin: Previous studies showed that factor Xa is preferentially inhibited by the (Z,Z) configuration isomer of (1), whilst trypsin binds equally well to both (E,Z) and...

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Identifiers

PMID: 12850145
DOI: 10.1016/s0022-2836(03)00617-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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