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Article

Trypsin mutants for structure-based drug design: expression, refolding and crystallisation.

Biological chemistry - 1 Jan 2000

Rauh Daniel, Reyda Sabine, Klebe Gerhard, Stubbs Milton T

Abstract excerpt

New techniques in drug discovery are essential for the fast and efficient development of novel innovative drugs to deal with the challenges of the future. Structure determinations of various members of serine proteinases have provided a basis for computer-based drug design within this class of enzymes. In many proteins of interest, however, this course is blocked through a lack of suitable crystals. As a strategy...

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PMID: 12437122
DOI: 10.1515/BC.2002.148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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