Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts.

Breast cancer research and treatment - 1 Jun 2003

Sartorius Carol A, Shen Tianjie, Horwitz Kathryn B

Abstract excerpt

Sixty to seventy percent of all primary human breast cancers are estrogen-dependent and express both estrogen (ER) and progesterone receptors (PR). Whereas expression of the two naturally occurring PR isoforms, PR-A and PR-B, is close to equimolar in normal human tissues, the ratio of the two receptors varies extensively in tumors. This is important since the two PR are functionally distinct and have differential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Estradiol

Share to Mice, Nude

Share to Receptors, Progesterone

Share to Transplantation, Heterologous

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12846413
DOI: 10.1023/a:1024031731269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenografts.PMID 12846413Read ↗

Progesterone-Independent Effects of Human Progesterone Receptors (PRs) in Estrogen Receptor-Positive Breast Cancer: PR Isoform-Specific Gene Regulation and Tumor BiologySemantic proximity Read ↗

New Human Breast Cancer Cells to Study Progesterone Receptor Isoform Ratio Effects and Ligand-independent Gene RegulationSemantic proximity Read ↗

Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts.Semantic proximity Read ↗

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer CellsSemantic proximity Read ↗

Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signalingSemantic proximity Read ↗

The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancerSemantic proximity Read ↗

Isoform-Specific Gene Regulation by Progesterone Receptors Drives Divergent Phenotypes in Breast Cancer CellsSemantic proximity Read ↗

Differential Regulation of Breast Cancer-Associated Genes by Progesterone Receptor Isoforms PRA and PRB in a New Bi-Inducible Breast Cancer Cell LineSemantic proximity Read ↗

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.Semantic proximity Read ↗

Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell linesSemantic proximity Read ↗

The A and B Isoforms of the Human Progesterone Receptor Operate through Distinct Signaling Pathways within Target CellsSemantic proximity Read ↗

Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivoin tumor xenografts and human breast tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.