Article
In vitro activity of gemifloxacin against clinical isolates of Neisseria gonorrhoeae with and without mutations in the gyrA gene.
International journal of antimicrobial agents - 1 Jul 2003
Ruiz Joaquim, Marco Francesc, Sierra Josep M, Aguilar Lorenzo, Garcia-Mendez Elena, Mensa Josep, Jiménez De Anta M Teresa, Vila Jordi
Abstract excerpt
The MIC of gemifloxacin and five other quinolones was tested against 31 clinical isolates of Neisseria gonorrhoeae; strains were analyzed for the presence of mutations in both the gyrA and parC genes. Only seven strains were resistant to nalidixic acid due to a mutation in the gyrA gene but not in the parC gene, with six and two considered intermediate to ciprofloxacin and levofloxacin, respectively. The activity...
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