Article
Chromatin structure of yeast minichromosomes containing triplet repeat sequences associated with human hereditary neurological diseases.
Nucleic acids research. Supplement (2001) - 1 Jan 2001
Shimizu M, Fujita R, Tomita N, Shindo H, Wells R D
Abstract excerpt
Expansion of triplet repeat sequences such as (CTG)n, (CGG)n, and (GAA)n causes human genetic diseases. Since DNA is packaged into arrays of nucleosomes in eukaryotic cells, chromatin may be involved in the mechanism of triplet repeat diseases. To elucidate this issue, we have examined effects of triplet repeat sequences on the chromatin organization in vivo using well defined yeast minichromosomes. We show here...
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