Article
Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockers.
Antimicrobial agents and chemotherapy - 1 Nov 1992
Samuelson J C, Burke A, Courval J M
Abstract excerpt
Previously a cloned emetine-resistant mutant of the protozoal parasite Entamoeba histolytica was shown to overexpress a gene for an ameba homolog of the mammalian P-glycoprotein, a plasma membrane pump that removes hydrophobic drugs from multidrug-resistant tumor cells. Three sets of experiments were performed to better characterize the multidrug-resistant phenotype of the emetine-resistant amebae. First, the...
Topics
- Animals
- Antidepressive Agents, Tricyclic
- Calcium Channel Blockers
- Chloroquine
- Clone Cells
- Drug Resistance
- Emetine
- Entamoeba histolytica
- Furans
- Iodoquinol
- Ion Channels