Article
A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector.
Hepatology (Baltimore, Md.) - 1 Jul 2003
Giannini Carlo, Morosan Serban, Tralhao J Guilherme, Guidotti Jacques Emmanuel, Battaglia Serena, Mollier Karine, Hannoun Laurent, Kremsdorf Dina, Gilgenkrantz Helene, Charneau Pierre
Abstract excerpt
Allogenic hepatocyte transplantation or autologous transplantation of genetically modified hepatocytes has been used successfully to correct congenital or acquired liver diseases and can be considered as an alternative to orthotopic liver transplantation. However, hepatocytes are neither easily maintained in culture nor efficiently genetically modified and are very sensitive to dissociation before their...
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