Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition.

Nucleic acids research - 1 Mar 2000

ten Asbroek A L, Fluiter K, van Groenigen M, Nooij M, Baas F

Abstract excerpt

The lack of specificity of cancer treatment causes damage to normal cells as well, which limits the therapeutic range. To circumvent this problem one would need to use an absolute difference between normal cells and cancer cells as therapeutic target. Such a difference exists in the genome of all individuals suffering from a tumor that is characterized by loss of genetic material [loss of heterozygosity (LOH)]....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Neoplasms

Share to Oligonucleotides, Antisense

Share to Polymorphism, Genetic

Share to RNA Polymerase II

Source

Open in PubMed Open full text

Identifiers

PMID: 10666454
DOI: 10.1093/nar/28.5.1133
PMCID: PMC102615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition.PMID 10666454Read ↗

Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II.Semantic proximity Read ↗

Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.Semantic proximity Read ↗

Killing cancer by targeting genes that cancer cells have lost: allele-specific inhibition, a novel approach to the treatment of genetic disorders.Semantic proximity Read ↗

Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A.Semantic proximity Read ↗

Selective killing of cancer cells based on loss of heterozygosity and normal variation in the human genome: a new paradigm for anticancer drug therapy.Semantic proximity Read ↗

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.Semantic proximity Read ↗

A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides.Semantic proximity Read ↗

Oligonucleotide-directed mutagenesis and targeted gene correction: a mechanistic point of view.Semantic proximity Read ↗

Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.Semantic proximity Read ↗

Modified oligonucleotides as tools for allele-specific amplification.Semantic proximity Read ↗

[Basic principles of the antisense strategy].Semantic proximity Read ↗

Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.