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Article

Antisense oligonucleotides to CFTR confer a cystic fibrosis phenotype on B lymphocytes.

The American journal of physiology - 1 Dec 1992

Krauss R D, Berta G, Rado T A, Bubien J K

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed at low levels in nonepithelial cells. Recently, we demonstrated that CFTR is responsible for cell cycle-dependent adenosine 3',5'-cyclic monophosphate-responsive Cl- permeability in lymphocytes. Agonist responsiveness of cystic fibrosis (CF) lymphocytes was restored by transfection with plasmid containing wild type CFTR cDNA. CFTR mRNA is...

Topics

B-Lymphocytes
Base Sequence
Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
Lymphocytes
Lymphoid Tissue
Membrane Proteins
Molecular Sequence Data
Oligonucleotides, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Permeability

Phenotype

RNA, Messenger

Source

Identifiers

PMID: 1282296
DOI: 10.1152/ajpcell.1992.263.6.C1147

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1282296-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Antisense oligonucleotides to CFTR confer a cystic fibrosis phenotype on B lymphocytes.PMID 1282296Read ↗

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