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Article

Antisense oligonucleotides to CFTR confer a cystic fibrosis phenotype on B lymphocytes.

The American journal of physiology - 1 Dec 1992

Krauss R D, Berta G, Rado T A, Bubien J K

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed at low levels in nonepithelial cells. Recently, we demonstrated that CFTR is responsible for cell cycle-dependent adenosine 3',5'-cyclic monophosphate-responsive Cl- permeability in lymphocytes. Agonist responsiveness of cystic fibrosis (CF) lymphocytes was restored by transfection with plasmid containing wild type CFTR cDNA. CFTR mRNA is...

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Source

Identifiers

PMID: 1282296
DOI: 10.1152/ajpcell.1992.263.6.C1147

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antisense oligonucleotides to CFTR confer a cystic fibrosis phenotype on B lymphocytes.PMID 1282296Read ↗

Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.Semantic proximity Read ↗

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Reversal of cystic fibrosis phenotype in a cultured Delta508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion.Semantic proximity Read ↗

Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial originSemantic proximity Read ↗

Gene-Specific Nonsense-Mediated mRNA Decay Targeting for Cystic Fibrosis TherapySemantic proximity Read ↗

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Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2K(b)-tsA58 transgene.Semantic proximity Read ↗

Epithelial cell specific properties and genetic complementation in a delta F508 cystic fibrosis nasal polyp cell line.Semantic proximity Read ↗

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Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis.Semantic proximity Read ↗

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