Gene targeting of a CFTR allele in HT29 human epithelial cells.

doi:10.1002/(SICI)1097-4652(199703)170:3<299::AID-JCP11>3.0.CO;2-A

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Gene targeting of a CFTR allele in HT29 human epithelial cells.

Journal of cellular physiology - 1 Mar 1997

Montrose-Rafizadeh C, Kole J, Bartkowski L M, Lee L H, Blackmon D L, Behnken S E, Gearhart J D, Cohn J A, Montrose M H

Abstract excerpt

HT29 cells endogenously express the cystic fibrosis transmembrane conductance regulator (CFTR) and have been used previously as a model to examine cellular regulation of CFTR expression and chloride secretory function. Homologous recombination has been used to specifically disrupt CFTR transcript...

Topics

Alleles
Alternative Splicing
Blotting, Northern
Blotting, Western
Cystic Fibrosis Transmembrane Conductance Regulator
Epithelial Cells
Gene Expression Regulation
Genetic Testing
Genetic Vectors
HT29 Cells
Humans
Mutagenesis
Phenotype
Polymerase Chain Reaction
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 9066787
DOI: 10.1002/(SICI)1097-4652(199703)170:3<299::AID-JCP11>3.0.CO;2-A

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9066787-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Transfection