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Article

Gene targeting of a CFTR allele in HT29 human epithelial cells.

Journal of cellular physiology - 1 Mar 1997

Montrose-Rafizadeh C, Kole J, Bartkowski L M, Lee L H, Blackmon D L, Behnken S E, Gearhart J D, Cohn J A, Montrose M H

Abstract excerpt

HT29 cells endogenously express the cystic fibrosis transmembrane conductance regulator (CFTR) and have been used previously as a model to examine cellular regulation of CFTR expression and chloride secretory function. Homologous recombination has been used to specifically disrupt CFTR transcription in the HT29-18-C1 subclone. Experiments demonstrate successful disruption of a CFTR allele by DNA constructs, which...

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Source

Identifiers

PMID: 9066787
DOI: 10.1002/(SICI)1097-4652(199703)170:3<299::AID-JCP11>3.0.CO;2-A

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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