Article
Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2008
Illek Beate, Maurisse Rosalie, Wahler Logan, Kunzelmann Karl, Fischer Horst, Gruenert Dieter C
Abstract excerpt
Little is known about the relationship between CF transmembrane conductance regulator (CFTR) gene expression and the corresponding transport of Cl. The phenotypic characteristics of polarized DeltaF508 homozygote CF bronchial epithelial (CFBE41o-) cells were evaluated following transfection with episomal expression vector containing either full-length (6.2kb) wild type (wt) and (4.7kb) DeltaF508CFTR cDNA....
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