Article
Effect of a new derivative of retinoic acid on proliferation and differentiation in human neuroblastoma cells.
Anticancer research - 1 Jan 2000
Bartolini G, Orlandi M, Ammar K, Magrini E, Ferreri A M, Rocchi P
Abstract excerpt
Neuroblastoma, a tumor originating from the sympathetic nervous system, is the most common extracranial malignant solid tumor of childhood. Human neuroblastoma cells may differentiate in vitro under treatment with a variety of biological agents and drugs. Among these, retinoic acid (RA) is quite potent and its effectiveness as a therapeutic agent is now being evaluated in clinical trials. As its pleiotropic...
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