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In Vivo Lysogenic Conversion of Tox <sup>−</sup> <i>Streptococcus pyogenes</i> to Tox <sup>+</sup> with Lysogenic Streptococci or Free Phage

21 Jun 2003

Abstract excerpt

Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eukaryote mediates the efficient induction of toxin-encoding temperate phage and the resultant...

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PMID: 12819060
DOI: 10.1128/iai.71.7.3782-3786.2003

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