The In Vitro Interaction of<i>Streptococcus pyogenes</i>with Human Pharyngeal Cells Induces a Phage-Encoded Extracellular DNase

Abstract excerpt

The role lysogenic bacteriophage play in the pathogenesis of the host bacterium is poorly understood. In a previous study, we found that streptococcal coculture with human pharyngeal cells resulted in the induction of lysogenic bacteriophage as well as the phage-associated streptococcal pyrogenic exotoxin C (SpeC). In this study, we have determined that in addition to SpeC induction, a number of other...

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