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Article

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

The Journal of biological chemistry - 29 Aug 2003

Murata Ken, Kumagai Hidetoshi, Kawashima Toshiyuki, Tamitsu Kaori, Irie Mariko, Nakajima Hideaki, Suzu Shinya, Shibuya Masabumi, Kamihira Shimeru, Nosaka Tetsuya, Asano Shigetaka, Kitamura Toshio

Abstract excerpt

The receptor tyrosine kinase FLT3 is constitutively activated by an internal tandem duplication (ITD) mutation within the juxtamembrane domain in 20-30% of patients with acute myeloid leukemia. In this study, we identified GTP-14564 as a specific kinase inhibitor for ITD-FLT3 and investigated the molecular basis of its specificity. GTP-14564 inhibited the growth of interleukin-3-independent Ba/F3 expressing...

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Identifiers

PMID: 12815052
DOI: 10.1074/jbc.M210405200

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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