Article
Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro.
Blood - 1 Nov 2003
Ochiai Naoya, Uchida Ryo, Fuchida Shin-ichi, Okano Akira, Okamoto Masashi, Ashihara Eishi, Inaba Tohru, Fujita Naohisa, Matsubara Hiroaki, Shimazaki Chihiro
Abstract excerpt
Ras gene mutations occur in 30% to 40% of patients with multiple myeloma (MM), and farnesylation is the first and most important step in the posttranslational modification of Ras proteins. R115777 is a newly synthesized potent farnesyl transferase inhibitor (FTI) and has recently demonstrated significant antitumor activities in vitro and in vivo. Therefore, we examined the effect of R115777 on the growth of fresh...
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