Article
Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain.
The Journal of biological chemistry - 2 Oct 1998
Schäcke H, Schumann H, Hammami-Hauasli N, Raghunath M, Bruckner-Tuderman L
Abstract excerpt
The cDNA sequence of human collagen XVII predicts an unusual type II transmembrane protein, but a biochemical characterization of this structure has not been accomplished yet. Using domain-specific antibodies against recombinant collagen XVII fragments, we identified two molecular forms of the collagen in human skin and epithelial cells. Full-length collagen XVII appeared as a homotrimeric transmembrane molecule...
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