Article
Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain.
The Journal of biological chemistry - 2 Oct 1998
Schäcke H, Schumann H, Hammami-Hauasli N, Raghunath M, Bruckner-Tuderman L
Abstract excerpt
The cDNA sequence of human collagen XVII predicts an unusual type II transmembrane protein, but a biochemical characterization of this structure has not been accomplished yet. Using domain-specific antibodies against recombinant collagen XVII fragments, we identified two molecular forms of the co...
Topics
- Amino Acid Chloromethyl Ketones
- Collagen
- Collagenases
- Disulfides
- Endopeptidases
- Furin
- Glycosylation
- Keratinocytes
- Membrane Proteins
- Mutation
- Peptide Fragments
- Protease Inhibitors
- Protein Conformation
- RNA, Messenger
- Recombinant Proteins
- Skin
- Subtilisins