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Article

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.

The Journal of biological chemistry - 29 Aug 2003

Bolger Graeme B, Peden Alexander H, Steele Michael R, MacKenzie Carolynn, McEwan David G, Wallace Derek A, Huston Elaine, Baillie George S, Houslay Miles D

Abstract excerpt

The cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4A5 interacted with the immunophilin XAP2 in a yeast two-hybrid assay. The interaction was confirmed in biochemical pull-down analyses. The interaction was specific, in that PDE4A5 did not interact with the closely related immunophilins AIPL1, FKBP51, or FKBP52. XAP2 also did not interact with other PDE4A isoforms or typical isoforms from the three other...

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Source

Identifiers

PMID: 12810716
DOI: 10.1074/jbc.M303269200

Genes

AIPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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