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Article

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.

The Journal of biological chemistry - 29 Aug 2003

Parfrey Helen, Mahadeva Ravi, Ravenhill Neil A, Zhou Aiwu, Dafforn Timothy R, Foreman Richard C, Lomas David A

Abstract excerpt

Conformational diseases are caused by a structural rearrangement within a protein that results in aberrant intermolecular linkage and tissue deposition. This is typified by the polymers that form with the Z deficiency variant of alpha 1-antitrypsin (Glu-342 --> Lys). These polymers are retained within hepatocytes to form inclusions that are associated with hepatitis, cirrhosis, and hepatocellular carcinoma. We...

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Identifiers

PMID: 12807889
DOI: 10.1074/jbc.M302646200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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