Article
Hydrogen peroxide-induced microsatellite instability in the Escherichia coli K-12 endogenous tonB gene.
Biochemical and biophysical research communications - 27 Jun 2003
Yamamura Eiji, Nunoshiba Tatsuo, Nohmi Takehiko, Yamamoto Kazuo
Abstract excerpt
Damage to DNA by reactive oxygen species may be a significant source of endogenous mutagenesis in aerobic organisms. Using an endogenous tonB gene as a mutation selective marker in Escherichia coli, we have examined whether endogenous oxidative mutagenesis can contribute to genetic instability. We have also used oxyR(+) and oxyR(-) strains to evaluate how hydrogen peroxide scavenging system can contribute to...
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