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Article

Antibody-Mediated Targeting of Replication-Competent Retroviral Vectors

20 May 2003

Abstract excerpt

Replication-competent murine leukemia virus (MLV) vectors can be engineered to achieve high efficiency gene transfer to solid tumors in vivo and tumor-restricted replication, however their safety can be further enhanced by redirecting tropism of the virus envelope. We have therefore tested the targeting capability and replicative stability of ecotropic and amphotropic replication-competent retrovirus (RCR)...

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PMID: 12804141
DOI: 10.1089/104303403765255174

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